Pheromone diffusers and calming sprays add a scent to the room, crate or car your dog spends time in. They may help some dogs, though the evidence for pheromones is weak.
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Most pheromone products use dog appeasing pheromone, a synthetic version of a pheromone that mother dogs produce shortly after giving birth. A 2021 review in Veterinary Evidence notes that it’s reported to have calming effects on young and adult dogs. It comes as plug-in diffusers, sprays and collars.
Other calming sprays rely on plant scents such as lavender. Our car anxiety guide covers the American Kennel Club’s advice to run herbal remedies past your vet first.
The 2021 review looked at eight controlled trials in dogs older than six months. It rated the evidence as weak and said a true clinical benefit is undetermined. It also found the pheromone unlikely to cause harm, and said it may still have a place in a wider management plan. The authors’ caution: it shouldn’t be used in place of treatments with established effects.
We picked these from popular, well-reviewed listings on Amazon.com in October 2026. We haven’t tested them ourselves. Each card says why the product is included and which dogs it may suit. Prices change often, so the button takes you to Amazon to check.
Why it's included A plug-in pheromone diffuser that comes with six refills, so it can run for a long stretch.
May suit Homes where a dog struggles when left alone or during noisy events. Plug it into the room your dog spends the most time in.
Why it's included A pheromone spray for the places your dog rests or travels, from the same range as the ThunderEase diffuser.
May suit Dogs who travel, visit the vet or have a bed or crate you can spray before a stressful event.
Why it's included A lavender spray for dogs and cats that also works as a coat detangler. It's made in the USA.
May suit Owners who'd like a scent-based option for travel, fireworks or vet visits. Try a little first, as some dogs dislike strong smells.
Why it's included A room spray with a fragrance blend NaturVet describes as simulated canine pheromones, plus rosemary and clove oils.
May suit Spraying a crate, car or room before storms, travel or grooming. It goes on surfaces, not on or in your dog.
When to talk to your vet. This page shares general information. If your dog panics, could hurt itself or changes suddenly, please speak with your vet. Read our disclaimer.
